Falsely Elevated Serum Creatinine Associated With IgM Paraproteinemia

Falsely high serum creatinine concentration associated with severe methanol intoxication.

A case of severe methanol intoxication (1300 mg/L) was associated with markedly increased serum creatinine (490 mg/L) despite normal urea values and the absence of any other signs of renal disease. These values declined progressively to normal, and the patient recovered with no visual impairment. Additional laboratory experimentation suggested that the high creatinine value was probably ascriba...

Falsely increased values for serum creatinine during therapy with cefoxitin.

Falsely elevated troponin levels.

To diagnose a myocardial infarction, an increase and/or fall in troponin values by at least one value > the 99th percentile in a healthy reference population is required, combined with other ischaemic signs or symptoms (1). Troponin T and troponin I are considered equal in diagnostics of myocardial infarction. There is only one manufacturer of tests for troponin T and thus only one reference ra...

AL amyloidosis associated with IgM paraproteinemia: clinical profile and treatment outcome.

AL amyloidosis associated with immunoglobulin M (IgM) paraproteinemia is rare. We report 103 consecutive such patients evaluated at the National Amyloidosis Centre (London, United Kingdom) between 1988 and 2006. Renal, cardiac, and lymph node amyloid was present in 53%, 35%, and 21% of patients, respectively, at presentation and 2 or more organs were involved in 54%. Seventy-three percent had a...

A case of IgM paraproteinemia in which serum free light chain values were within reference intervals.

To the Editor: We read with interest the recent paper on the combination of serum protein electrophoresis (SPEP) and serum free light chain (FLC) assay as a potential alternative to SPEP and urine protein electrophoresis (UPEP) screening for paraproteinemia (1 ), as well as the accompanying editorial on sensitivity and specificity issues of the serum FLC assay (2 ). This assay, which first beca...